铁基材料在生物可降解血管支架领域的研究进展

许雅南; 王伟强; 杨帅康; 王轶农

doi:10.7513/j.issn.1004-7638.2023.04.023

铁基材料在生物可降解血管支架领域的研究进展

doi: 10.7513/j.issn.1004-7638.2023.04.023

大连理工大学材料科学与工程学院, 辽宁大连116024

基金项目: 国家重点研究发展计划（2019YFA0705300）；中央高校基础研究基金（DUT22YG118，LD202219）。

详细信息

作者简介:
许雅南，1996年出生，女，内蒙古赤峰人，博士研究生，主要研究方向为医用金属材料，E-mail：yananxu@mail.dlut.edu.cn

通讯作者:
王伟强，1974年出生，男，博士，辽宁大连人，副教授，主要研究方向为医用金属材料，E-mail：wangwq@dlut.edu.cn

中图分类号: TG174,TB34
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出版历程
- 收稿日期: 2023-02-20
- 刊出日期: 2023-08-30

Research progress of biodegradable iron-based materials for vascular stents

School of Materials Science and Engineering , Dalian University of Technology, Dalian 116024, Liaoning, China

摘要

摘要: 铁基可降解金属材料是最有潜力替代永久性血管支架的材料之一，降解速率慢是制约其发展的主要原因。对可降解铁基血管支架材料近年来的研究进行了梳理、总结和展望，发现众多研究者通过调整其微观组织结构、表面处理、合金化、和“复合”材料设计等方式对其生物相容性、腐蚀降解行为、机械性能和磁性能等方面进行了优化，以期设计理想铁基可降解血管支架材料。然而，单一的微观组织结构调整，虽然保证了纯铁的生物相容性，但对降解性能的提升有限；通过特殊的表面处理技术，也可以提高纯铁近表区域的腐蚀速率，但是难以优化基体的腐蚀性能；合金化可以均匀地提高材料的综合性能，但是单一合金化的方式所制备的合金和理想血管支架的性能要求仍然有差距。认为在合金化的基础上进行“复合”材料设计，可以更好地优化材料的综合性能。
- 铁基合金 /
- 血管支架 /
- 降解性能 /
- 生物相容性
Abstract: Iron-based biodegradable metal material is one of the most potential materials to replace permanent vascular stents. The slow degradation rate is the main problem hindering its development. Many researchers optimized its biocompatibility, corrosion and degradation behaviors, mechanical properties and magnetic properties by adjusting its microstructure, surface treatment, alloying, and "composite" material design, aiming for the ideal iron-based biodegradable stent materials. Although the pure iron compatibility can be ensured by microstructure adjustment, its degradability improvement is limited. While, it is hard to optimize the corrosion resistance properties of pure iron matrix, despite the fact that the corrosion rate of the close-to-surface regions can be enhanced by specific surface treatments. Among these ways, the comprehensive properties of materials were optimized via "composite" materials designed by alloying. However, a great improvement is still required for the alloying materials to satisfy the properties of ideal stents. This work summarized the researches of iron-based biodegradable stent materials from the above aspects and suggestions on the future research directions were also proposed.
- iron-based alloys /
- vascular stent /
- degradation properties /
- biocompatibility

HTML全文

图 1 理想可降解血管支架治疗过程

(a)血管病变狭窄后植入支架；(b)血管重塑；(c)支架在体内均匀降解；(d）支架完全在体内消失

Figure 1. Ideal biodegradable vascular stent treatment process

下载: 全尺寸图片幻灯片

图 2 "复合" 材料设计示意

Figure 2. Schematic diagram of "composite" material design

下载: 全尺寸图片幻灯片

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