TiO2 microspheres with different morphology were synthesized by a simple hydrothermal method.The as-prepared samples were characterized by X-ray diffraction(XRD),scanning electron microscope(SEM).The photocatalytic activities of the samples for methyl orange degradation were studied.The results indicate that the core-shell structure TiO2 microspheres have favorable photocatalytic performance.Under the UV light for 1 h,the degradation rate of the methyl orange reaches to 90%,that is 20% faster than the others when the TiO2 samples have different morphology.