With the aid of extraction complex of C thin film,TEM and energy dispersion X-ray spectrum (EDX),the dissolve rule of Nb,V and Ti in Nb-V-Ti and V-Ti microalloyed steel was studied by isothermal holding at different temperatures and for different time.The results show that the large precipitate which is Ti-rich with a little Nb and V precipitate in solidification and form complex (Nb,V,Ti)(C,N) precipitate.The dissolution of V in V-Ti microalloyed steel is restrained by Ti.