Gr1 titanium plate is commonly used for explosion metal clad plates. Great area plate needs to be tailor-welded. In order to ensure plasticity of Gr1 titanium plate satisfy requirements for subsequent explosive cladding process,different welding parameters and wire-feed modes are chosen for tailor-welding 5.5 mm Gr1 titanium plate. Through the comparative analysis of metallography,hardness,tension and bend,influence of different process parameters on the weld structure and mechanical properties are investigated. The results show that self-fusion tailor-welding without welding wire under the welding conditions of I = 90 A,U = 10 V,v = 4.8 mm/s can achieve significant fraction of fine α grains and good comprehensive mechanical performance at the weld. Tailor-welding Gr1 titanium plate can meet the requirements for explosion metal clad plate.