Volume 44 Issue 4
Aug.  2023
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Xu Yanan, Wang Weiqiang, Yang Shuaikang, Wang Yinong. Research progress of biodegradable iron-based materials for vascular stents[J]. IRON STEEL VANADIUM TITANIUM, 2023, 44(4): 158-166. doi: 10.7513/j.issn.1004-7638.2023.04.023
Citation: Xu Yanan, Wang Weiqiang, Yang Shuaikang, Wang Yinong. Research progress of biodegradable iron-based materials for vascular stents[J]. IRON STEEL VANADIUM TITANIUM, 2023, 44(4): 158-166. doi: 10.7513/j.issn.1004-7638.2023.04.023

Research progress of biodegradable iron-based materials for vascular stents

doi: 10.7513/j.issn.1004-7638.2023.04.023
  • Received Date: 2023-02-20
  • Publish Date: 2023-08-30
  • Iron-based biodegradable metal material is one of the most potential materials to replace permanent vascular stents. The slow degradation rate is the main problem hindering its development. Many researchers optimized its biocompatibility, corrosion and degradation behaviors, mechanical properties and magnetic properties by adjusting its microstructure, surface treatment, alloying, and "composite" material design, aiming for the ideal iron-based biodegradable stent materials. Although the pure iron compatibility can be ensured by microstructure adjustment, its degradability improvement is limited. While, it is hard to optimize the corrosion resistance properties of pure iron matrix, despite the fact that the corrosion rate of the close-to-surface regions can be enhanced by specific surface treatments. Among these ways, the comprehensive properties of materials were optimized via "composite" materials designed by alloying. However, a great improvement is still required for the alloying materials to satisfy the properties of ideal stents. This work summarized the researches of iron-based biodegradable stent materials from the above aspects and suggestions on the future research directions were also proposed.
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  • [1]
    Ma Liyuan, Wang Zengwu, Fan Jing, et al. Summary of《China cardiovascular health and disease report 2021》[J]. Chinese Journal of Interventional Cardiology, 2022,30(7):487−496. (马丽媛, 王增武, 樊静, 等. 中国心血管健康与疾病报告2021概要[J]. 中国介入心脏病学杂志, 2022,30(7):487−496.

    Ma Liyuan, Wang Zengwu, Fan Jing, et al. Summary of《China cardiovascular health and disease report 2021》[J]. Chinese Journal of Interventional Cardiology, 2022, 30(7): 487-496
    Daemen J, Boersma E, Flather M, et al. Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis with 5-year patient-level data from the ARTS, ERACI-II, MASS-II, and SoS trials[J]. Circulation, 2008,118(11):1146−1154. doi: 10.1161/circulationaha.107.752147
    Serruys P W, Jaegere P D, Kiemeneij F, et al. A Comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease[J]. New England Journal of Medicine, 1994, 331: 489 - 495.
    Onuma Y, Serruys P W. Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization[J]. Circulation, 2011,123(7):779−797. doi: 10.1161/CIRCULATIONAHA.110.971606
    Zheng Y F, Gu X N, Witte F. Biodegradable metals[J]. Materials Science and Engineering, 2014,77:1−34. doi: 10.1016/j.mser.2014.01.001
    Loffredo S, Hermawan H, Vedani M, et al. 20 - Absorbable metals for cardiovascular applications[M]. Niinomi M, ed. Metals for Biomedical Devices (Second Edition). Woodhead Publishing, 2019: 523-543.
    Liu Y, Zheng Y F, Chen X H, et al. Fundamental theory of biodegradable metals—definition, criteria, and design[J]. Advanced Functional Materials, 2019,29(18):1805402. doi: 10.1002/adfm.201805402
    Chen Q Z, Thouas G A. Metallic implant biomaterials[J]. Materials Science and Engineering, 2015,87:1−57. doi: 10.1016/j.mser.2014.10.001
    Underwood E J. Trace elements in human and animal nutrition[J]. Soil Science, 1963, 95(4): 287.
    Schinhammer M, Hanzi A C, Loffler J F, et al. Design strategy for biodegradable Fe-based alloys for medical applications[J]. Acta Biomaterialia, 2010,6(5):1705−1713. doi: 10.1016/j.actbio.2009.07.039
    Peuster M, Wohlsein P, Brügmann M, et al. A novel approach to temporary stenting: Degradable cardiovascular stents produced from corrodible metal - Results 6-18 months after implantation into New Zealand white rabbits[J]. Heart, 2001,86(5):563−569. doi: 10.1136/heart.86.5.563
    Peuster M, Hesse C, Schloo T, et al. Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta[J]. Biomaterials, 2006,27(28):4955−4962. doi: 10.1016/j.biomaterials.2006.05.029
    Ron W, Rajbabu P, Richard B, et al. Short-term effects of biocorrodible iron stents in porcine coronary arteries[J]. Journal of Interventional Cardiology, 2008,21(1):15−20. doi: 10.1111/j.1540-8183.2007.00319.x
    Obayi C S, Tolouei R, Mostavan A, et al. Effect of grain sizes on mechanical properties and biodegradation behavior of pure iron for cardiovascular stent application[J]. Biomatter, 2016,6(1):959874. doi: 10.4161/21592527.2014.959874
    Moravej M, Purnama A, Fiset M, et al. Electroformed pure iron as a new biomaterial for degradable stents: In vitro degradation and preliminary cell viability studies[J]. Acta Biomaterialia, 2010,6(5):1843−1851. doi: 10.1016/j.actbio.2010.01.008
    Qi Y, Li X, He Y, et al. Mechanism of acceleration of iron corrosion by a polylactide coating[J]. ACS Applied Materials & Interfaces, 2019,11(1):202−218. doi: 10.1021/acsami.8b17125
    Gorejova R, Orinakova R, Macko J, et al. Electrochemical behavior, biocompatibility and mechanical performance of biodegradable iron with PEI coating[J]. Journal of Biomedical Materals Research Part A, 2022,110(3):659−671. doi: 10.1002/jbm.a.37318
    Cheng J, Huang T, Zheng Y F. Relatively uniform and accelerated degradation of pure iron coated with micro-patterned Au disc arrays[J]. Materials Science and Engineering:C, 2015,48:679−687. doi: 10.1016/j.msec.2014.12.053
    Huang T, Zheng Y. Uniform and accelerated degradation of pure iron patterned by Pt disc arrays[J]. Scientific Reports, 2016,6:23627. doi: 10.1038/srep23627
    Zhou J C, Yang Y Y, Alonso Frank M, et al. Accelerated degradation behavior and cytocompatibility of pure iron treated with sandblasting[J]. ACS Applied Materials & Interfaces, 2016,8(40):26482−26492. doi: 10.1021/acsami.6b07068
    Bagherifard S, Molla M F, Kajanek D, et al. Accelerated biodegradation and improved mechanical performance of pure iron through surface grain refinement[J]. Acta Biomaterialia, 2019,98:88−102. doi: 10.1016/j.actbio.2019.05.033
    Wang H N, Zheng Y, Li Y, et al. Improvement of in vitro corrosion and cytocompatibility of biodegradable Fe surface modified by Zn ion implantation[J]. Applied Surface Science, 2017,403:168−176. doi: 10.1016/j.apsusc.2017.01.158
    Chen H Y, Zhang E L, Yang K. Microstructure, corrosion properties and bio-compatibility of calcium zinc phosphate coating on pure iron for biomedical application[J]. Materials Science and Engineering:C, 2014,34:201−206. doi: 10.1016/j.msec.2013.09.010
    Zhu S, Huang N, Shu H, et al. Corrosion resistance and blood compatibility of lanthanum ion implanted pure iron by MEVVA[J]. Applied Surface Science, 2009,256(1):99−104. doi: 10.1016/j.apsusc.2009.07.082
    Zhu S F, Huang N, Xu L, et al. Biocompatibility of Fe–O films synthesized by plasma immersion ion implantation and deposition[J]. Surface and Coatings Technology, 2009,203(10):1523−1529. doi: 10.1016/j.surfcoat.2008.11.033
    Hermawan H, Dubé M D. Development of degradable Fe-35Mn alloy for biomedical application[J]. Advanced Materials Research, 2006,15-17:107−112. doi: 10.4028/www.scientific.net/AMR.15-17.107
    Hermawan H, Purnama A, Dube D, et al. Fe-Mn alloys for metallic biodegradable stents: degradation and cell viability studies[J]. Acta Biomaterialia, 2010,6(5):1852−1860. doi: 10.1016/j.actbio.2009.11.025
    Capek J, Kubasek J, Vojtech D, et al. Microstructural, mechanical, corrosion and cytotoxicity characterization of the hot forged FeMn30(%) alloy[J]. Materials Science and Engineering:C, 2016,58:900−908. doi: 10.1016/j.msec.2015.09.049
    Traverson M, Heiden M, Stanciu L A, et al. In Vivo evaluation of biodegradability and biocompatibility of Fe30Mn alloy[J]. Veterinary and Comparative Orthopaedics and Traumatology, 2018,31(1):10−16. doi: 10.3415/VCOT-17-06-0080
    Sotoudehbagha P, Sheibani S, Khakbiz M, et al. Novel antibacterial biodegradable Fe-Mn-Ag alloys produced by mechanical alloying[J]. Materials Science and Engineering:C, 2018,88:88−94. doi: 10.1016/j.msec.2018.03.005
    Niendorf T, Brenne F, Hoyer P, et al. Processing of new materials by additive manufacturing: Iron-based alloys containing silver for biomedical applications[J]. Metallurgical and Materials Transactions A, 2015,46(7):2829−2833. doi: 10.1007/s11661-015-2932-2
    Hong D, Chou D T, Velikokhatnyi O I, et al. Binder-jetting 3D printing and alloy development of new biodegradable Fe-Mn-Ca/Mg alloys[J]. Acta Biomaterialia, 2016,45:375−386. doi: 10.1016/j.actbio.2016.08.032
    Xu W, Lu X, Tan L, et al. Study on properties of a novel biodegradable Fe-30Mn-1C alloy[J]. Acta Metallurgica Sinica, 2011,47(10):1342−1347. doi: 10.3724/SP.J.1037.2011.00258
    Harjanto S, Pratesa Y, Suharno B, et al. Corrosion behavior of Fe-Mn-C alloy as degradable materials candidate fabricated via powder metallurgy process[J]. Advanced Materials Research, 2012: 386-389.
    Liu B, Zheng Y F, Ruan L Q. In vitro investigation of Fe30Mn6Si shape memory alloy as potential biodegradable metallic material[J]. Materials Letters, 2011,65(3):540−543. doi: 10.1016/j.matlet.2010.10.068
    Drevet R, Zhukova Y, Kadirov P, et al. Tunable corrosion behavior of calcium phosphate coated Fe-Mn-Si alloys for bone implant applications[J]. Metallurgical and Materials Transactions A, 2018,49(12):6553−6560. doi: 10.1007/s11661-018-4907-6
    Hufenbach J, Wendrock H, Kochta F, et al. Novel biodegradable Fe-Mn-C-S alloy with superior mechanical and corrosion properties[J]. Materials Letters, 2017,186:330−333. doi: 10.1016/j.matlet.2016.10.037
    Hufenbach J, Kochta F, Wendrock H, et al. S and B microalloying of biodegradable Fe-30Mn-1C - effects on microstructure, tensile properties, in vitro degradation and cytotoxicity[J]. Materials & Design, 2018,142:22−35. doi: 10.1016/j.matdes.2018.01.005
    Venezuela J, Dargusch M S. Addressing the slow corrosion rate of biodegradable Fe-Mn: Current approaches and future trends[J]. Current Opinion in Solid State and Materials Science, 2020,24(3):100822. doi: 10.1016/j.cossms.2020.100822
    Lin W, Zhang G, Cao P, et al. Cytotoxicity and its test methodology for a bioabsorbable nitrided iron stent[J]. Journal of Biomedical Materials Researcheh, 2015,103(4):764−776. doi: 10.1002/jbm.b.33246
    Lin W, Qin L, Qi H, et al. Long-term in vivo corrosion behavior, biocompatibility and bioresorption mechanism of a bioresorbable nitrided iron scaffold[J]. Acta Biomaterialia, 2017,54:454−468. doi: 10.1016/j.actbio.2017.03.020
    Wang H, Zheng Y, Liu J, et al. In vitro corrosion properties and cytocompatibility of Fe-Ga alloys as potential biodegradable metallic materials[J]. Materials Science and Engineering:C, 2017,71:60−66. doi: 10.1016/j.msec.2016.09.086
    Capek J, Msallamova S, Jablonska E, et al. A novel high-strength and highly corrosive biodegradable Fe-Pd alloy: Structural, mechanical and in vitro corrosion and cytotoxicity study[J]. Materials Science and Engineering:C, 2017,79:550−562. doi: 10.1016/j.msec.2017.05.100
    Mostavan A, Paternoster C, Tolouei R, et al. Effect of electrolyte composition and deposition current for Fe/Fe-P electroformed bilayers for biodegradable metallic medical applications[J]. Materials Science and Engineering:C, 2017,70(1):195−206. doi: 10.1016/j.msec.2016.08.026
    Liu B, Zheng Y F. Effects of alloying elements (Mn, Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron[J]. Acta Biomaterialia, 2011,7(3):1407−1420. doi: 10.1016/j.actbio.2010.11.001
    Xu Y N, Wang W Q, Yu F, et al. Effects of pulse frequency and current density on microstructure and properties of biodegradable Fe-Zn alloy[J]. Journal of Materials Research and Technology, 2022,18:44−58. doi: 10.1016/j.jmrt.2022.02.096
    Xu Y N, Wang W Q, Yu F Y, et al. The enhancement of mechanical properties and uniform degradation of electrodeposited Fe-Zn alloys by multilayered design for biodegradable stent applications[J]. Acta Biomaterialia, 2023. https://doi.org/10.1016/j.actbio.2023.02.029.
    Zheng J F, Xi Z W, Li Y, et al. Long-term safety and absorption assessment of a novel bioresorbable nitrided iron scaffold in porcine coronary artery[J]. Bioactive Materials, 2022,17:496−505. doi: 10.1016/j.bioactmat.2022.01.005
    Zheng J F, Qiu H, Tian Y, et al. Preclinical evaluation of a novel sirolimus-eluting iron bioresorbable coronary scaffold in porcine coronary artery at 6 months[J]. JACC:Cardiovascular Interventions, 2019,12(3):245−255. doi: 10.1016/j.jcin.2018.10.020
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