Titanium tetrachloride was produced in industrial experimental scale by the fluid-bed chlorinating process with the mixture of Panzhihua synthetic rutile (w(TiO2)=91.04%,w(CaO+MgO)=0.94%) and high titanium slag (w(TiO2)=88.05%,w(CaO+MgO)=1.85%),in which the ratio of high-grade titanium slag Panzhihua synthetic rutile was 50∶50~0∶100 in weight.The major equipment was the f800 mm fluid-bed reactor in Zunyi Titanium Co.,Ltd.The results show that the fluidizing behavior is good,the deslagging is smooth,the chlorination ratio of TiO2 is up to 95%,and the quality of the titanium tetrachloride product measures up.