Abstract: There is a large amount of vanadium titanium magnetite resource in Panzhihua area. Sulfide in the resource is associated with cobalt,nickel,copper and other valuable metals. In this paper sulfide had been investigated by the laser micro spectral analysis,spectral semi-quantitative analysis and electron probe quantitative analysis method in vanadium titanium magnetite in Panzhihua region via the process mineralogy in order to find out the composition of sulfide,the main sulfide minerals distribution and major valuable elements distribution state,etc. According to the results of process mineralogy investigation,sulfide mainly distributes in pyrrhotite,secondly in chalcopyrite,pyrite and nickel pyrite. Pyrrhotite contains cobalt,nickel and copper elements. Besides,the characteristics of sulfide in the mining area of different ore block and the course of the sulfide in dressing products have been gained. Research results are expected to help to achieve the reasonable development and utilization of the vanadium titanium magnetite sulfide ore of cobalt,nickel and copper.